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To learn more about the CamKIIa gene, read the project description below or view the full project summary in the Research Objectives section.
“The Cerebellum and Its Role in Autism” began:
To study the effects of a mutation in the CamKIIa gene associated with autism, the researchers will use a technique called “gene targeting” to make targeted changes to the genome of mice. The study will be conducted by Joan S. McCarrey, Ph.D., Associate Professor of Neurobiology, Psychiatry, and Behavior.
The purpose of this study is to begin to understand how a mutation in the CamKIIa gene affects brain circuits and behavior. Specifically, the researchers will study how the mice with the mutant CamKIIa gene behave when they are stimulated with sensory stimuli.
The researchers will discover functions of the cerebellum, a part of the brain that has been extensively studied but remains largely unknown. Cerebellar research has been important for understanding how the cerebellum supports the development of motor skills and sensory perception. As such, studies